Author: Ivanova, Elena; Berger, Audrey; Scherrer, Anne; Alkalaeva, Elena; Strub, Katharina
Title: Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits Document date: 2015_3_11
ID: 64cnoqpi_3
Snippet: Translation initiation is regulated by the orchestrated action of multiple control mechanisms, many of which remain to be elucidated. We have previously shown that the noncoding, retrotransposon-derived Alu RNA in complex with the heterodimeric protein SRP9/14 (forming together the Alu RNP) is able to diminish polysome formation in a wheat germ translation system and thus, most likely interferes with translation initiation (4) . These data raised.....
Document: Translation initiation is regulated by the orchestrated action of multiple control mechanisms, many of which remain to be elucidated. We have previously shown that the noncoding, retrotransposon-derived Alu RNA in complex with the heterodimeric protein SRP9/14 (forming together the Alu RNP) is able to diminish polysome formation in a wheat germ translation system and thus, most likely interferes with translation initiation (4) . These data raised the intriguing possibility that Alu RNPs are involved in a novel translational control pathway.
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