Author: Ivanova, Elena; Berger, Audrey; Scherrer, Anne; Alkalaeva, Elena; Strub, Katharina
Title: Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits Document date: 2015_3_11
ID: 64cnoqpi_69
Snippet: The competition between Alu RNA and 40S for SRP9/14 binding would explain why RNPs comprising Alu RNAs representing the Alu domain of 7SL RNA, which has the highest affinity for SRP9/14 (29, 30) , did not confer an inhibitory activity to the RNP. The affinity of 40S for SRP9/14 would be insufficient to compete with these RNAs for SRP9/14 binding. A plausible explanation for the mutually exclusive binding of SRP9/14 to Alu RNA or to 40S subunits i.....
Document: The competition between Alu RNA and 40S for SRP9/14 binding would explain why RNPs comprising Alu RNAs representing the Alu domain of 7SL RNA, which has the highest affinity for SRP9/14 (29, 30) , did not confer an inhibitory activity to the RNP. The affinity of 40S for SRP9/14 would be insufficient to compete with these RNAs for SRP9/14 binding. A plausible explanation for the mutually exclusive binding of SRP9/14 to Alu RNA or to 40S subunits is to presume that the basic â¤-sheet formed by the two proteins, which represents the major binding domain for Alu RNA (37), will also be involved in binding the 40S subunit, most likely via the 18S ribosomal RNA. The targeted delivery of SRP9/14 to a functionally important site in 40S also predicts that the Alu RNA itself transiently interact with the 40S subunit guiding SRP9/14 to its proper binding site.
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