Selected article for: "analytical sensitivity and specificity clinical analytical sensitivity"
Author: Kim, Mi-Na; Ko, Young Jin; Seong, Moon-Woo; Kim, Jae-Seok; Shin, Bo-Moon; Sung, Heungsup
Title: Analytical and Clinical Validation of Six Commercial Middle East Respiratory Syndrome Coronavirus RNA Detection Kits Based on Real-Time Reverse-Transcription PCR
  • Document date: 2016_6_24
    • ID: 1le537yd_36
    Snippet: There were some noteworthy limitations of this study, including: 1) the number of specimens used to test clinical sensitivity was relatively small; 2) the reproducibility of the assay results was not validated; and 3) the effects of inhibition were qualitatively estimated. In conclusion, the commercial kits evaluated in this study demonstrated variable analytical sensitivities; however, the overall clinical sensitivity and specificity were same a.....
    Document: There were some noteworthy limitations of this study, including: 1) the number of specimens used to test clinical sensitivity was relatively small; 2) the reproducibility of the assay results was not validated; and 3) the effects of inhibition were qualitatively estimated. In conclusion, the commercial kits evaluated in this study demonstrated variable analytical sensitivities; however, the overall clinical sensitivity and specificity were same and were sufficient for diagnosing MERS-CoV infection. The performance of the individual kits could be improved in terms of their analytical sensitivity, and identification of PCR inhibition with the use of appropriate internal controls is essential.

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