Author: Kim, Mi-Na; Ko, Young Jin; Seong, Moon-Woo; Kim, Jae-Seok; Shin, Bo-Moon; Sung, Heungsup
Title: Analytical and Clinical Validation of Six Commercial Middle East Respiratory Syndrome Coronavirus RNA Detection Kits Based on Real-Time Reverse-Transcription PCR Document date: 2016_6_24
ID: 1le537yd_36
Snippet: There were some noteworthy limitations of this study, including: 1) the number of specimens used to test clinical sensitivity was relatively small; 2) the reproducibility of the assay results was not validated; and 3) the effects of inhibition were qualitatively estimated. In conclusion, the commercial kits evaluated in this study demonstrated variable analytical sensitivities; however, the overall clinical sensitivity and specificity were same a.....
Document: There were some noteworthy limitations of this study, including: 1) the number of specimens used to test clinical sensitivity was relatively small; 2) the reproducibility of the assay results was not validated; and 3) the effects of inhibition were qualitatively estimated. In conclusion, the commercial kits evaluated in this study demonstrated variable analytical sensitivities; however, the overall clinical sensitivity and specificity were same and were sufficient for diagnosing MERS-CoV infection. The performance of the individual kits could be improved in terms of their analytical sensitivity, and identification of PCR inhibition with the use of appropriate internal controls is essential.
Search related documents:
Co phrase search for related documents- analytical sensitivity and clinical sensitivity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61
- analytical sensitivity and clinical sensitivity test: 1, 2, 3
- analytical sensitivity and commercial kit: 1, 2, 3, 4, 5, 6, 7
- analytical sensitivity and individual kit: 1
- analytical sensitivity and internal control: 1, 2, 3, 4, 5, 6
- analytical sensitivity and overall clinical sensitivity: 1, 2
- analytical sensitivity and PCR inhibition: 1, 2, 3, 4, 5, 6
- analytical sensitivity and specificity overall clinical sensitivity: 1
- analytical sensitivity and study evaluate: 1, 2, 3, 4, 5, 6, 7, 8
- analytical sensitivity and variable analytical sensitivity: 1, 2
- appropriate internal control and commercial kit: 1
- appropriate internal control and internal control: 1, 2, 3, 4
- assay result and clinical sensitivity: 1, 2, 3, 4
- assay result and inhibition effect: 1
- assay result and internal control: 1
- assay result and PCR inhibition: 1
- assay result and study evaluate: 1, 2
- assay result reproducibility and clinical sensitivity: 1
Co phrase search for related documents, hyperlinks ordered by date