Selected article for: "lung viral titer and viral titer"
Author: Song, Jae-Hyoung; Shim, Aeri; Kim, Yeon-Jeong; Ahn, Jae-Hee; Kwon, Bo-Eun; Pham, Thuy Trang; Lee, Jongkook; Chang, Sun-Young; Ko, Hyun-Jeong
Title: Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection
  • Document date: 2018_5_2
    • ID: 0bwf8f1i_31
    Snippet: To assess the antiviral activity of pochonin D against HRV1B, mice were intraperitoneally administered 200 μg/kg of pochonin D, at 1 h prior and 4 h after intranasal HRV1B infection. We performed placebo infection in control mice, and administered vehicle intraperitoneally in HRV1B-infected mice as a negative control. After 8 h of infection, we sacrificed the mice and obtained lung samples. Real-time PCR analysis of viral mRNA in lung tissues re.....
    Document: To assess the antiviral activity of pochonin D against HRV1B, mice were intraperitoneally administered 200 μg/kg of pochonin D, at 1 h prior and 4 h after intranasal HRV1B infection. We performed placebo infection in control mice, and administered vehicle intraperitoneally in HRV1B-infected mice as a negative control. After 8 h of infection, we sacrificed the mice and obtained lung samples. Real-time PCR analysis of viral mRNA in lung tissues revealed that the virus titer was significantly reduced in pochonin D-treated mice compared to that of vehicle-treated mice after HRV1B infection ( Fig. 2A) . We thus confirmed that pochonin D has an anti-HRV activity in vitro as well as in vivo when administered systemically via the intraperitoneal route.

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