Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection

Song, Jae-Hyoung; Shim, Aeri; Kim, Yeon-Jeong; Ahn, Jae-Hee; Kwon, Bo-Eun; Pham, Thuy Trang; Lee, Jongkook; Chang, Sun-Young; Ko, Hyun-Jeong

HRV1B-infected mice showed serious hemorrhage, edema, and cell infiltration compared to control mice, and the pochonin D treatment group showed reduced damage induced by HRV1B infection. We also observed the changes in the airway cilia of the trachea by SEM (Fig. 5C ). Uninfected mice showed abundant cilia in the trachea with regular arrangement and intact septum. However, the trachea of rhinovirus-infected mice was damaged, and we could observe abnormal cilia with some phlegm. On the contrary, the condition of the trachea in HRV1B-infected mice treated with pochonin D showed amelioration of damage caused by HRV1B infection compared to that in vehicle-treated mice. Despite the presence of phlegm and decreased number of cilia, the cilia in pochonin D-treated mice after HRV1B infection were relatively intact. These results suggest that the lung and trachea were significantly damaged by rhinovirus infection, and treatment with pochonin D protected the mice from histological damage induced by HRV1B.