Author: Draz, Mohamed Shehata; Shafiee, Hadi
Title: Applications of gold nanoparticles in virus detection Document date: 2018_2_15
ID: 1xjmlwqr_28
Snippet: AuNPs were utilized to develop a novel immuno-PCR assay for the immunological detection of HTNV nucleocapsid protein [96] . This assay mainly relies on the enhanced surface area of AuNPs to prepare dually functionalized antibody-oligonucleotide conjugates that exceptionally carry specific monoclonal antibodies to label the target HTNV antigen; the assay also involves barcoding DNA for signal amplification (Fig. 4A ). This assay could optimally de.....
Document: AuNPs were utilized to develop a novel immuno-PCR assay for the immunological detection of HTNV nucleocapsid protein [96] . This assay mainly relies on the enhanced surface area of AuNPs to prepare dually functionalized antibody-oligonucleotide conjugates that exceptionally carry specific monoclonal antibodies to label the target HTNV antigen; the assay also involves barcoding DNA for signal amplification (Fig. 4A ). This assay could optimally detect concentrations as low as 200 aM of purified or spiked antigen samples, which is ~7 orders of magnitude more sensitive than conventional ELISA. The high detection sensitivity together with the targeting of HTNV nucleocapsid protein [105] , which is the most abundant viral component synthesized post virus infection, makes this assay a promising candidate method for the early diagnosis and control of HTNV.
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