2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

There was a statistically significant difference at all fractional GE between GET following metoclopramide and erythromycin treatments when compared to placebo (p = 0.002 -0.049 and p = 0.001 -0.015 for metoclopramide and erythromycin respectively) and exenatide Sixty dogs anesthetized for elective ovariectomy were evaluated for GER and 27 dogs identified with GER and having contents with a pH of < 4 were included in the study. An esophageal pH/impedance catheter (Divarsatekâ„¢, Milwaukee) was placed shortly following anesthesia using endoscopic guidance with the catheter tip placed approximately 3 cm cranial to the lower esophageal sphincter. A GER episode was defined as an orally progressing decrease in impedance (50% decrement in ohms) from the pre-episodic esophageal baseline recording. When esophageal pH < 4 remained at the conclusion of the surgery esophageal lavage was performed. Tap water in 60 mL aliquots was instilled through a gastric tube and carefully suctioned. If after an interval of 2 minutes post lavage esophageal pH was still under 4, another aliquot was instilled and again suctioned until pH > 4. Paired t test, Wilcoxon matched pairs test and Spearman';s rank correlation coefficient were used to analyze parametric and nonparametric data.