2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

The new VetScan cPL rapid test for the VetScan VUE shows poor linearity. This is of clinical significance as the working range of this assay is very narrow, making dilution necessary for samples with higher cPLI concentrations. Also, the assay is not very precise (mean %CV: 25.1%). Finally, inter-assay variability is unacceptably high (mean % CV: 31.8%), affecting the actual diagnostic bin in many cases. In conclusion, the VetScan cPL rapid test for the VetScan VUE lacked linearity, precision, and reproducibility. range: 4 to 5) and 6 (8 %), over-conditioned (median: 6 to 6 -7; range: 5 -6 to 8). Sixty-one dogs (88 %) had documented weight loss at the time of diagnosis; 30 (43 %) had severe (≥10 %), 22 (32 %) had moderate (5 -9.9 %), and 9 (13 %) had mild (0.1-4.9%) loss. Two dogs were lost to follow-up and 29 out of 69 dogs (42 %) died or were euthanized following treatment failure. There were no significant effects of body condition score, percentage weight loss, body weight, appetite, serum albumin, cholesterol, cobalamin, and folate concentrations, canine chronic enteropathy activity index, and duration of signs on mortality (P>0.05). However, dogs that had higher caloric intake at diagnosis had increased number of days to death or euthanasia following treatment failure (P = 0.002, correlation coefficient = 0.571).