Selected article for: "cell line and primary macrophage"

Title: 2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018
  • Document date: 2018_10_25
  • ID: 60ceejq1_384
    Snippet: In addition, when compared to bacteria from normal control animals, IBD fecal bacteria significantly stimulated higher levels of phagocytosis in canine primary macrophage (P = 0.02) as well as in DH82 cells; canine macrophage tumor cell line (P = 0.04). The upregulation of surface activation markers (MHC II, CD40, CD86 and CD80) in response from both groups was comparable. Phagocytosis of IBD gut bacteria activated macrophages and stimulated high.....
    Document: In addition, when compared to bacteria from normal control animals, IBD fecal bacteria significantly stimulated higher levels of phagocytosis in canine primary macrophage (P = 0.02) as well as in DH82 cells; canine macrophage tumor cell line (P = 0.04). The upregulation of surface activation markers (MHC II, CD40, CD86 and CD80) in response from both groups was comparable. Phagocytosis of IBD gut bacteria activated macrophages and stimulated higher production of TNF-α than normal gut bacteria (P = 0.047). In contrast, IL-10 production from primary macrophages incubated with IBD fecal bacteria was significantly decreased compared to normal flora from healthy dogs (P = 0.045).

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