2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

The mean body weight of hyperthyroid treated cats (n = 1,281) at pretreatment and at all post-treatment time points was significantly less than control cats (n = 12,810) (all P values < 0.01). Hyperthyroid cats had a significantly lower mean weight pretreatment, and at 1-30 days and 31-60 days versus 90-120 days (all P values ≤ 0.03). Pretreatment creatinine was significantly decreased in comparison to all post-treatment time points (all P values < 0.001). Creatinine was significantly increased at 91-120 days in comparison to all other time points (all P values ≤ 0.007). The mean creatinine of hyperthyroid cats was significantly less than in control cats pre-treatment and up to the 61-90 day post-treatment time period (all P values < 0.01). Pretreatment SDMA was significantly decreased in comparison to all post-treatment time points (all P values < 0.001). However, after the increase in SDMA at 1-30 days, there was no significant difference in mean SDMA concentrations throughout the remainder of the treatment periods. In addition, compared to the control cats, the mean SDMA of hyperthyroid cats was only significantly lower pre-treatment (P < 0.001) but not at any post-treatment time point.