Title: 2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018 Document date: 2018_10_25
ID: 60ceejq1_273
Snippet: Intensive staining localized to cell membrane was defined as HER2 protein overexpression. The aim of this study was to assess the toxicity and efficacy of a doxorubicin/ cytarabine (DC) combination protocol in dogs with acute myeloid leukemia (AML). A cohort of 6 dogs with persistent cytopenia, and bone marrow cytology and/or core biopsy diagnosis of AML were treated with same day doxorubicin at 30 mg/m 2 or 1 mg/kg IV over 20 minutes, followed b.....
Document: Intensive staining localized to cell membrane was defined as HER2 protein overexpression. The aim of this study was to assess the toxicity and efficacy of a doxorubicin/ cytarabine (DC) combination protocol in dogs with acute myeloid leukemia (AML). A cohort of 6 dogs with persistent cytopenia, and bone marrow cytology and/or core biopsy diagnosis of AML were treated with same day doxorubicin at 30 mg/m 2 or 1 mg/kg IV over 20 minutes, followed by cytarabine at 300 mg/m 2 with constant rate IV infusion over 4 hours, every 14 days. Prednisone (2 mg/kg PO q24h) was also administered. Hematologic results, adverse effects and outcomes were assessed every 1-2 weeks during DC therapy.
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