Selected article for: "plasminogen activator and tissue plasminogen activator"
Title: 2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018
  • Document date: 2018_10_25
    • ID: 60ceejq1_425
    Snippet: Sarah Shropshire, Christine Olver Colorado State University, Fort Collins, CO, USA Greyhounds have several hematologic differences from other breeds of dogs, including higher hematocrit and hemoglobin concentration and lower neutrophil and platelet counts. It has also been observed that some Greyhounds have a propensity to bleed excessively 36-48 hours following minor traumas or routine surgeries. The exact etiology behind this bleeding is unknow.....
    Document: Sarah Shropshire, Christine Olver Colorado State University, Fort Collins, CO, USA Greyhounds have several hematologic differences from other breeds of dogs, including higher hematocrit and hemoglobin concentration and lower neutrophil and platelet counts. It has also been observed that some Greyhounds have a propensity to bleed excessively 36-48 hours following minor traumas or routine surgeries. The exact etiology behind this bleeding is unknown however several studies have postulated this may occur due to hyperfibrinolysis. Dynamic viscoelastic testing using thromboelastography (TEG) allows for not only assessment of coagulation but also fibrinolysis. TEG has been performed previously in Greyhounds but no study has investigated fibrinolysis variables via TEG in the presence of tissue plasminogen activator (tPA) in healthy Greyhounds. Therefore, the purpose of this study was to evaluate if Greyhounds appear hyperfibrinolytic as compared to non-Greyhounds.

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