2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

Owner Survey of Amoxicillin-Clavulanic Acid Side Effects in Cats with and without Azotemic CKD Cats with chronic kidney disease (CKD) have an anecdotal increased frequency of side effects with amoxicillin-clavulanic acid such as decreased appetite, vomiting and diarrhea in comparison to cats with normal kidney function. In human patients with decreased kidney function, it has been shown that potentiated penicillins, like amoxicillin-clavulanic acid, have impaired clearance (by as much as 90% in severe renal impairment). This impaired clearance results in higher serum concentrations in comparison to patients with normal kidney function and reduction of dosing interval is recommended to avoid side effects. The purpose of this study was to determine the frequency of side effects in cats with and without azotemia, with the hypothesis that cats with azotemic CKD will have an increased frequency of side effects.