Author: Richard, A; Tulasne, D
Title: Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis Document date: 2012_3_8
ID: 3hxau5vt_21
Snippet: Herpex simplex virus 1 (HSV-1) causes lifelong infections affecting between 50 and 90% of the global population. HSV-1 exerts antiapoptotic properties against numerous stimuli. But some variants including d120 mutant induce apoptosis and under these conditions, infected cell protein no. 22 (ICP22 or M r 37,500 protein) leads to an additional product (M r 35,000) that can result in vitro from ICP22 cleavage by caspase 3. 49 Neither the identity of.....
Document: Herpex simplex virus 1 (HSV-1) causes lifelong infections affecting between 50 and 90% of the global population. HSV-1 exerts antiapoptotic properties against numerous stimuli. But some variants including d120 mutant induce apoptosis and under these conditions, infected cell protein no. 22 (ICP22 or M r 37,500 protein) leads to an additional product (M r 35,000) that can result in vitro from ICP22 cleavage by caspase 3. 49 Neither the identity of the caspase site nor the biological relevance of ICP22 cleavage has been further investigated yet.
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