Author: Weishan Huang; Sabrina Solouki; Chavez Carter; Song-Guo Zheng; Avery August
Title: Beyond type 1 regulatory T cells: co-expression of LAG3 and CD49b in IL-10-producing T cell lineages Document date: 2018_6_30
ID: ivyp5cgz_35
Snippet: Using Tr1 cell clones derived from human naïve CD4 + T cells and purified by an IL-10 297 secretion assay, Gagliani, Roncarolo and colleagues identified co-expression of LAG3, CD49b 298 and CD226 as cell surface signatures of IL-10-producing CD4 + T cells, and demonstrated that co-299 expression of LAG3 and CD49b is sufficient to distinguish Foxp3 -IL-10 high Tr1 cells from T helper 300 and/or regulatory subsets that expressed lower levels of or.....
Document: Using Tr1 cell clones derived from human naïve CD4 + T cells and purified by an IL-10 297 secretion assay, Gagliani, Roncarolo and colleagues identified co-expression of LAG3, CD49b 298 and CD226 as cell surface signatures of IL-10-producing CD4 + T cells, and demonstrated that co-299 expression of LAG3 and CD49b is sufficient to distinguish Foxp3 -IL-10 high Tr1 cells from T helper 300 and/or regulatory subsets that expressed lower levels of or no IL-10 in both mouse and human 301
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