2015 ACVIM Forum Research Abstract Program

The results of this study suggested that cholangiohepatitis is a rare condition in adult cattle. Ante mortem diagnosis may be challenging because clinical signs are unspecific and laboratory results resemble those of a cow suffering of hepatic lipidosis in combination with an inflammatory process (e.g acute metritis or acute mastitis). Although the number of animals included in this study was small, it appeared that the diagnosis of cholangioheaptitis carries guarded prognosis. Values for pharmacokinetic variables are usually obtained in healthy animals, whereas drugs are frequently administered to diseased animals. There is therefore an urgent need to determine whether dosage protocols need to be altered in sick animals. Consequently, we compared pharmacokinetic values of intra-mammary cefquinome in healthy goats and goats with experimentally induced mastitis.