2016 ACVIM Forum Research Abstract Program

Obstruction of CSF flow in the subarachnoid space can be associated with severe and life-threatening (fecal incontinence is a common reason for euthanasia) neurologic deficits. Our results suggest that subarachnoid-subarachnoid shunting can be an effective surgical technique to ameliorate or prevent progression of associated clinical signs. Meningiomas and gliomas are the most common intracranial neoplasms in dogs, and definitive diagnosis is often problematic due to the cost and invasiveness of an intracranial biopsy. Biomarkers in serum, urine, and/or CSF can provide adjunctive diagnostic data in conjunction with standard techniques such as magnetic resonance imaging. The cycloogygenase pathway has been identified as a key player in cancer progression, and several pathway products including thromboxane A 2 (TxA 2 ) are over expressed in a variety of human cancers, including gliomas.