Selected article for: "acute respiratory distress syndrome and avian influenza infection"
Author: Yuan, S
Title: Drugs to cure avian influenza infection – multiple ways to prevent cell death
  • Document date: 2013_10_3
    • ID: 617zol31_1
    Snippet: The infection of avian influenza induces reactive oxygen species accumulation, causing hyperimmune response to the virus, which may have adverse effects on vital organs and result in high pathogenicity and mortality. Clinical care of acute respiratory distress syndrome may result in ischemia reperfusion injury to alveolar cells that are poorly ventilated or poorly supplied with blood. The main mechanism includes mitochondrial permeability transit.....
    Document: The infection of avian influenza induces reactive oxygen species accumulation, causing hyperimmune response to the virus, which may have adverse effects on vital organs and result in high pathogenicity and mortality. Clinical care of acute respiratory distress syndrome may result in ischemia reperfusion injury to alveolar cells that are poorly ventilated or poorly supplied with blood. The main mechanism includes mitochondrial permeability transition and the release of apoptotic mediators. Combinations of immunomodulators and antiviral agents significantly reduced mortality in mice infected with the avian influenza virus (AIV). However, the reduced mortality rate was still relatively high (over 10%). Virus neuraminidase digests lysosomal membrane glycoproteins, which induces lysosome lysis and the release of lysosomal proteases. This is another mechanism of AIVinduced cell death.

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