Author: Abes, Rachida; Moulton, Hong M.; Clair, Philippe; Yang, Sung-Tae; Abes, Said; Melikov, Kamran; Prevot, Paul; Youngblood, Derek S.; Iversen, Patrick L.; Chernomordik, Leonid V.; Lebleu, Bernard
Title: Delivery of steric block morpholino oligomers by (R-X-R)(4) peptides: structure–activity studies Document date: 2008_9_16
ID: 5j496cx0_33
Snippet: (R-X-R) 4 -PMO conjugates with X spacers of increasing lengths (from 2 to 8 atoms) ( Figure 1A ) have thus been compared in terms of affinity for a model heparan sulfate on a Hi-trap Heparin column ( Figure 1B ). Increasing spacer length leads to decreased affinity as monitored by the NaCl concentration required for elution in keeping with published data (20) . Conjugates in this series were then compared for their ability to promote splicing cor.....
Document: (R-X-R) 4 -PMO conjugates with X spacers of increasing lengths (from 2 to 8 atoms) ( Figure 1A ) have thus been compared in terms of affinity for a model heparan sulfate on a Hi-trap Heparin column ( Figure 1B ). Increasing spacer length leads to decreased affinity as monitored by the NaCl concentration required for elution in keeping with published data (20) . Conjugates in this series were then compared for their ability to promote splicing correction in dose-response experiments ( Figure 1C and data not shown). Increasing the length of the spacer led to increased luciferase expression with an optimum for the C5-linked material.
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