Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3-Triazolylbenzyl-aminophosphonates

Ouahrouch, Abdelaaziz; Taourirte, Moha; Schols, Dominique; Snoeck, Robert; Andrei, Graciela; Engels, Joachim W.; Lazrek, Hassan B.

Currently, most of the human beings in the world suffer from different kinds of diseases caused by DNA and RNA viruses. These diseases are mostly diagnosed but difficult to cure. Vaccination is a reliable tool to fight viral diseases, but it is only available against few viruses. The difficulties associated with national or worldwide vaccination programs make antiviral chemotherapy an even more practical approach in the fight against epidemic viral infections. Nucleoside analogs are synthetic compounds that are structurally similar to natural nucleosides and can serve as building blocks of DNA and RNA. They can act as competitive inhibitors of viral and cellular DNA and RNA polymerases or alternatively can be incorporated into growing DNA and RNA strands causing chain termination [1] .