Determining the impact of commercial feed additives as potential porcine epidemic diarrhea virus mitigation strategies as determined by polymerase chain reaction analysis and bioassay()

Gebhardt, Jordan T; Woodworth, Jason C; Jones, Cassandra K; Tokach, Mike D; Gauger, Philip C; Main, Rodger G; Zhang, Jianqiang; Chen, Qi; DeRouchey, Joel M; Goodband, Robert D; Stark, Charles R; Bergstrom, Jon R; Bai, Jianfa; Dritz, Steve S

Although the use of commercial formaldehyde has shown significant efficacy in reducing the quantity of detectible PEDV genetic material (Dee et al., 2015 (Dee et al., , 2016 Cochrane et al., 2016b) , concerns arise when considering the implementation of such procedures including the requirement for specialized equipment within feed-manufacturing facilities. Therefore, although effective at mitigating risk of PEDV transmission in an experimental setting, the use of formaldehyde is not a solution for all situations. Other compounds when added to feed and feed ingredients have shown promising efficacy at reducing amount of quantifiable RNA as well as reducing infectivity via swine bioassay-most notably MCFAs (Cochrane et al. 2015; Cochrane et al., 2016b; Dee et al., 2016) . The downfall with the use of MCFA is there are currently no economical sources that are commercially available.