2016 ACVIM Forum Research Abstract Program

Good correlation was found between scintigraphy and sonography for the 75% (287 AE 67 [mean AE SD] and 306 AE 28 minutes respectively, r = 0.85, P < 0.02) and 90% GE times (340 AE 77 and 381 AE 29 minutes respectively, r = 0.85; P < 0.02). Ultrasound evaluation of antral cross-sectional area is a valid alternative to scintigraphy in the late phase of GE in healthy cats. Impairment of gallbladder motility might be responsible for the pathogenesis of gallbladder mucocele and biliary sludge in dogs and the improvement of the gallbladder motility has a possibility to exert the preventive effects on the progression of the gallbladder diseases. However, little has been studied on the treatments to enhance the gallbladder motility in dogs. It was reported that 5-HT 4 receptor agonist improves gallbladder emptying in human gallstone patients, and that mosapride, which is a selective 5-HT 4 receptor agonist practically used for prokinetics of canine gastrointestinal disease, induces the increase of motilin, which is a physiological inducer of gallbladder motor activity. In this study, we investigated the effects of mosapride on the postprandial gallbladder motility and the plasma levels of motilin in dogs with or without biliary sludge. Furthermore, we examined the expression of 5-HT 4 receptor using gallbladder tissue of a normal dog.