Author: Nasir, Arshan; Caetano-Anollés, Gustavo
Title: A phylogenomic data-driven exploration of viral origins and evolution Document date: 2015_9_25
ID: 49360l2a_30_1
Snippet: bacterial peptidoglycan layers and facilitate viral entry. We speculate that this capability was transferred to eukaryotic cells from viruses to block bacterial infections in eukaryotes. Another relatively widespread FSF was the "Origin of replication binding domain, RBD-like" (d.89.1) FSF, which was detected in~16% of the sampled viruses. Both the abe core and FSFs shared with cells spanned the entire nd axis. Thus, viral proteomes encode both v.....
Document: bacterial peptidoglycan layers and facilitate viral entry. We speculate that this capability was transferred to eukaryotic cells from viruses to block bacterial infections in eukaryotes. Another relatively widespread FSF was the "Origin of replication binding domain, RBD-like" (d.89.1) FSF, which was detected in~16% of the sampled viruses. Both the abe core and FSFs shared with cells spanned the entire nd axis. Thus, viral proteomes encode both very ancient and very derived FSFs. The former group was most likely inherited vertically from the common ancestor of cells and viruses, whereas the latter could be a result of recent HGT gains from cells or shared innovation. The enrichment of very ancient FSFs in the abe core present in viruses infecting the three superkingdoms provides strong support to their ancient origin. The origin of VSFs, on the other hand, marks the onset of modern virocell life cycles.
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