Selected article for: "affinity receptor and receptor affinity"
Author: SAKAI, Kosei; YONEZAWA, Tomohiro; YAMAWAKI, Hideyuki; OYAMADA, Toshifumi
Title: Alteration of somatostatin receptor 2 expression in canine mammary gland tumor
  • Document date: 2015_5_18
    • ID: 765ufb5i_1
    Snippet: Somatostatin (SST) is a peptide hormone produced in the hypothalamus, pancreas and intestine; it regulates both endocrine and exocrine gland function [17] , and downregulates cell proliferation in various tissues of many species including dogs [1, 3, 4, 10, 14] . Among the SST receptor (SSTR) superfamily, SSTR2 is the most dominant receptor, with the highest affinity to the ligand and the strongest antiproliferative effect [3] . In human breast c.....
    Document: Somatostatin (SST) is a peptide hormone produced in the hypothalamus, pancreas and intestine; it regulates both endocrine and exocrine gland function [17] , and downregulates cell proliferation in various tissues of many species including dogs [1, 3, 4, 10, 14] . Among the SST receptor (SSTR) superfamily, SSTR2 is the most dominant receptor, with the highest affinity to the ligand and the strongest antiproliferative effect [3] . In human breast cancer, tumor tissues that express SSTRs are less aggressive and more differentiated than tumors with little SSTRs expression, which are massive and highly malignant [5] . These findings lead to the speculation that SSTR signal transduction is closely related to the malignancy of human breast cancer.

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