Author: Lin, Tsai-Yu; Chin, Christopher R.; Everitt, Aaron R.; Clare, Simon; Perreira, Jill M.; Savidis, George; Aker, Aaron M.; John, Sinu P.; Sarlah, David; Carreira, Erick M.; Elledge, Stephen J.; Kellam, Paul; Brass, Abraham L.
Title: Amphotericin B Increases Influenza A Virus Infection by Preventing IFITM3-Mediated Restriction Document date: 2013_11_21
ID: 10ynhrl3_19
Snippet: Consistent with these results, mouse embryonic fibroblasts (MEFs) derived from Ifitm3 À/À mice were more susceptible to infection than WT MEFs, and this difference was largely erased with AmphoB exposure (Figure 6D , E). Similar to above, the Ifitm3 À/À cells treated with AmphoB demonstrated a slightly increased infection with X-31, suggesting that Ifitm2 or an additional component is also being overcome by AmphoB. We conclude that a clinical.....
Document: Consistent with these results, mouse embryonic fibroblasts (MEFs) derived from Ifitm3 À/À mice were more susceptible to infection than WT MEFs, and this difference was largely erased with AmphoB exposure (Figure 6D , E). Similar to above, the Ifitm3 À/À cells treated with AmphoB demonstrated a slightly increased infection with X-31, suggesting that Ifitm2 or an additional component is also being overcome by AmphoB. We conclude that a clinical formulation of AmphoB, AmBisome, produces the functional equivalent of an Ifitm3-null state, and by so doing converts a mild illness into a life-threatening infection.
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