Author: Jartti, Tuomas; Smits, Hermelijn H.; Bønnelykke, Klaus; Bircan, Ozlem; Elenius, Varpu; Konradsen, Jon R.; Maggina, Paraskevi; Makrinioti, Heidi; Stokholm, Jakob; Hedlin, Gunilla; Papadopoulos, Nikolaos; Ruszczynski, Marek; Ryczaj, Klaudia; Schaub, Bianca; Schwarze, Jürgen; Skevaki, Chrysanthi; Stenberg-Hammar, Katarina; Feleszko, Wojciech
Title: Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments Document date: 2018_11_25
ID: 4svg09dt_20
Snippet: Most studies focused on RSV bronchiolitis, and the reported associations include genes related to immune regulation and surfactant proteins. 25 Several of these genes have also been associated with asthma, 25 suggesting that the association between RSV bronchiolitis and later asthma development might partly be explained by shared genetics. 1, 18 Nevertheless, bronchiolitis is a poorly defined and highly heterogeneous disease entity with variabili.....
Document: Most studies focused on RSV bronchiolitis, and the reported associations include genes related to immune regulation and surfactant proteins. 25 Several of these genes have also been associated with asthma, 25 suggesting that the association between RSV bronchiolitis and later asthma development might partly be explained by shared genetics. 1, 18 Nevertheless, bronchiolitis is a poorly defined and highly heterogeneous disease entity with variability in clinical presentation, age at infection, and triggering factors, as well as in the underlying genetic mechanisms. For example, it would be expected that RV bronchiolitis in older children, 18 a phenotype also characterized by a higher risk of asthma predisposition, would also have a higher degree of shared heritability with asthma.
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