Author: Jartti, Tuomas; Smits, Hermelijn H.; Bønnelykke, Klaus; Bircan, Ozlem; Elenius, Varpu; Konradsen, Jon R.; Maggina, Paraskevi; Makrinioti, Heidi; Stokholm, Jakob; Hedlin, Gunilla; Papadopoulos, Nikolaos; Ruszczynski, Marek; Ryczaj, Klaudia; Schaub, Bianca; Schwarze, Jürgen; Skevaki, Chrysanthi; Stenberg-Hammar, Katarina; Feleszko, Wojciech
Title: Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments Document date: 2018_11_25
ID: 4svg09dt_4
Snippet: To that end, we propose a differentiation of bronchiolitis subtypes by specific viruses and a broad inclusion of children by extending the upper age limit from 6 or 12 months up to 2 years. Recent data clearly indicate that the two major viral causes of bronchiolitis, respiratory syncytial virus (RSV) and rhinovirus (RV), have distinct genetics, pathogenetic mechanisms, clinical characteristics, and responses to treatments both regarding short-an.....
Document: To that end, we propose a differentiation of bronchiolitis subtypes by specific viruses and a broad inclusion of children by extending the upper age limit from 6 or 12 months up to 2 years. Recent data clearly indicate that the two major viral causes of bronchiolitis, respiratory syncytial virus (RSV) and rhinovirus (RV), have distinct genetics, pathogenetic mechanisms, clinical characteristics, and responses to treatments both regarding short-and long-term outcomes. 1, [5] [6] [7] Thus, a general bronchiolitis diagnosis should be revisited, as the identification of different viruses associated with severe bronchiolitis should improve our understanding of the disease and open avenues for precision medicine.
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