Selected article for: "alpha chain and beta chain"
Author: Banu, Nasirah; Chia, Adeline; Ho, Zi Zong; Garcia, Alfonso Tan; Paravasivam, Komathi; Grotenbreg, Gijsbert M.; Bertoletti, Antonio; Gehring, Adam J.
Title: Building and Optimizing a Virus-specific T Cell Receptor Library for Targeted Immunotherapy in Viral Infections
  • Document date: 2014_2_25
    • ID: 44w6omdp_10
    Snippet: In a subset of TCR transduced T cells we also analyzed the production of TNF-a and IL-2. Similar to the results with IFN-c, we found that the optimal orientation of the TCR expression cassettes resulted in an increase in the frequency of TNF-a and IL-2 producing cells within the population of transduced T cells (Fig. 3 D&E) . These data confirm that, in addition to codon optimization and adding the TCR alpha and beta chains to a single cassette, .....
    Document: In a subset of TCR transduced T cells we also analyzed the production of TNF-a and IL-2. Similar to the results with IFN-c, we found that the optimal orientation of the TCR expression cassettes resulted in an increase in the frequency of TNF-a and IL-2 producing cells within the population of transduced T cells (Fig. 3 D&E) . These data confirm that, in addition to codon optimization and adding the TCR alpha and beta chains to a single cassette, the simple modification of inverting the TCR alpha and beta chain orientation can have a significant impact on TCR expression and T cell function in engineered T cells.

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