Author: Banu, Nasirah; Chia, Adeline; Ho, Zi Zong; Garcia, Alfonso Tan; Paravasivam, Komathi; Grotenbreg, Gijsbert M.; Bertoletti, Antonio; Gehring, Adam J.
Title: Building and Optimizing a Virus-specific T Cell Receptor Library for Targeted Immunotherapy in Viral Infections Document date: 2014_2_25
ID: 44w6omdp_24
Snippet: In conclusion, we have developed a virus-specific T cell receptor library targeting different viral infections. Using straightforward approaches we optimized TCR expression and tried to minimize alterations to the wild type amino acid sequence to reduce potential immunogenicity 37 . The modifications led to increased TCR expression and function. Banks of ready-made virus-specific T cells for adoptive cell therapy are being used 38 and the ability.....
Document: In conclusion, we have developed a virus-specific T cell receptor library targeting different viral infections. Using straightforward approaches we optimized TCR expression and tried to minimize alterations to the wild type amino acid sequence to reduce potential immunogenicity 37 . The modifications led to increased TCR expression and function. Banks of ready-made virus-specific T cells for adoptive cell therapy are being used 38 and the ability to generate unlimited numbers of highly efficient virus-specific T cells using TCR gene transfer could facilitate this approach.
Search related documents:
Co phrase search for related documents- adoptive cell therapy and cell therapy: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41
- adoptive cell therapy and gene transfer: 1, 2
- adoptive cell therapy and TCR gene transfer: 1, 2
- adoptive cell therapy and viral infection: 1, 2
- amino acid and cell receptor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- amino acid and cell therapy: 1, 2
- amino acid and gene transfer: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- amino acid and increase TCR expression: 1
- amino acid and potential immunogenicity: 1
- amino acid and straightforward approach: 1
- amino acid and TCR expression: 1, 2
- amino acid and TCR expression optimize: 1
- amino acid and TCR gene transfer: 1
- amino acid and type amino acid: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76
- amino acid and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- amino acid and wild type amino acid: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26
- amino acid and wild type amino acid sequence: 1, 2, 3, 4
- approach facilitate and unlimited number: 1
- cell receptor and different viral infection: 1, 2
Co phrase search for related documents, hyperlinks ordered by date