Selected article for: "astrocytes expression and MHC class"
Title: Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains
  • Document date: 1991_4_1
    • ID: 6acjgug3_5
    Snippet: Cytokine production has also been implicated in contributing to autoimmune diseases (see for review, reference 802 Tumor Necrosis Factor Expression by Astrocytes 29). Since cytokines play a major role in regulating immune responses, aberrant expression may be a factor in the initiation and perpetuation of autoimmunity. Of particular interest is the fact that the genes for TNF-a and functionally related TNF-a (lymphotoxin) map within the MHC gene .....
    Document: Cytokine production has also been implicated in contributing to autoimmune diseases (see for review, reference 802 Tumor Necrosis Factor Expression by Astrocytes 29). Since cytokines play a major role in regulating immune responses, aberrant expression may be a factor in the initiation and perpetuation of autoimmunity. Of particular interest is the fact that the genes for TNF-a and functionally related TNF-a (lymphotoxin) map within the MHC gene complex (30) . Since many autoimmune diseases are strongly associated with class I and II MHC gene products, TNF-a/TNF-0 are plausible candidates for cytokines involved with autoimmunity.

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