Author: Mok, Hoyin; Cheng, Xing; Xu, Qi; Zengel, James R; Parhy, Bandita; Zhao, Jackie; Wang, C. Kathy; Jin, Hong
Title: Evaluation of Measles Vaccine Virus as a Vector to Deliver Respiratory Syncytial Virus Fusion Protein or Epstein-Barr Virus Glycoprotein gp350 Document date: 2012_2_16
ID: 3qdjmb2j_1
Snippet: Live attenuated viruses have been developed and used to help protect humans from various infectious diseases. Live attenuated vaccine viruses simulate natural infection and are highly immunogenic and effective in inducing both humoral and cellular immune responses. Because of their demonstrated safety and effectiveness against infectious diseases, different live attenuated vaccine viruses have been explored as vectors to express heterologous anti.....
Document: Live attenuated viruses have been developed and used to help protect humans from various infectious diseases. Live attenuated vaccine viruses simulate natural infection and are highly immunogenic and effective in inducing both humoral and cellular immune responses. Because of their demonstrated safety and effectiveness against infectious diseases, different live attenuated vaccine viruses have been explored as vectors to express heterologous antigens [1] . Measles vaccine (MV) strain has a long history of demonstrated safety in humans. It induces long lasting immunity including antibody and T cell responses [2] [3] [4] . Aerosol administration of measles vaccine is also being developed and has been shown to induce similar or better immunogenicity compared to conventional subcutaneous or intramuscular vaccination [5, 6] . This aerosol administration route may offer advantages in helping to protect individuals from mucosal pathogens.
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