Author: Sabath, Niv; Wagner, Andreas; Karlin, David
Title: Evolution of Viral Proteins Originated De Novo by Overprinting Document date: 2012_7_19
ID: 629fwmgk_52
Snippet: For each of our 12 overlapping gene pairs (table 1) , we collected the full sequences of the ancestral and the de novo genes, the sequence of the region of the genome where they overlapped, and the sequences of other genes annotated in the genome in which they occur. We also collected this information for homologous overlapping genes in related genomes within the focal clade (see earlier). As all subsequent analyses are carried on sequences withi.....
Document: For each of our 12 overlapping gene pairs (table 1) , we collected the full sequences of the ancestral and the de novo genes, the sequence of the region of the genome where they overlapped, and the sequences of other genes annotated in the genome in which they occur. We also collected this information for homologous overlapping genes in related genomes within the focal clade (see earlier). As all subsequent analyses are carried on sequences within the focal clade, which is defined by the distribution of the de novo protein rather than the ancestral protein, it is independent of the BLAST cutoff. We used these data to study the following three properties of ancestral and de novo genes:
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