Author: Jaïs, Philippe H; Decroly, Etienne; Jacquet, Eric; Le Boulch, Marine; Jaïs, Aurélien; Jean-Jean, Olivier; Eaton, Heather; Ponien, Prishila; Verdier, Fréderique; Canard, Bruno; Goncalves, Sergio; Chiron, Stéphane; Le Gall, Maude; Mayeux, Patrick; Shmulevitz, Maya
Title: C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system Document date: 2019_3_18
ID: 6nq7y1qe_85
Snippet: Another interesting application of this system relates to RNA virus production. Recently, Eaton et al. (83) have shown that C3P3-G1 system increases reovirus protein expression by 5-to 10-fold and reovirus rescue by 100-fold, in comparison to the current reverse genetics system. Reoviruses are nonpathogenic viruses that demonstrate antitumor activity and are being explored for cancer therapy (84) . These results are therefore encouraging for usin.....
Document: Another interesting application of this system relates to RNA virus production. Recently, Eaton et al. (83) have shown that C3P3-G1 system increases reovirus protein expression by 5-to 10-fold and reovirus rescue by 100-fold, in comparison to the current reverse genetics system. Reoviruses are nonpathogenic viruses that demonstrate antitumor activity and are being explored for cancer therapy (84) . These results are therefore encouraging for using the C3P3-G1 system to produce viruses containing 5 -capped RNAs, including Retroviridae, Rhabdoviridae, Paramyxoviridae, Filoviridae or Reoviridae.
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