Selected article for: "apoptosis caspase and caspase activation"

Author: Richard, A; Tulasne, D
Title: Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis
  • Document date: 2012_3_8
  • ID: 3hxau5vt_17
    Snippet: Transmissible gastroenteritis coronavirus (TGEV) causes acute and fatal diarrhea in newborn piglets. TGEV infection is able to induce caspases 3, 6, 7, 8 and 9 activation 43,44 and the cleavage of the structural NP N, leading to a stable 41-kDa fragment (N 0 ). 44 N protein is targeted in vitro by caspases 6 and 7, and less efficiently by caspase 3. In HRT18jap1 cells, the infection causes apoptosis but is not productive, suggesting that caspase .....
    Document: Transmissible gastroenteritis coronavirus (TGEV) causes acute and fatal diarrhea in newborn piglets. TGEV infection is able to induce caspases 3, 6, 7, 8 and 9 activation 43,44 and the cleavage of the structural NP N, leading to a stable 41-kDa fragment (N 0 ). 44 N protein is targeted in vitro by caspases 6 and 7, and less efficiently by caspase 3. In HRT18jap1 cells, the infection causes apoptosis but is not productive, suggesting that caspase activation (and possibly N caspase cleavage) prevents progeny virion generation. However, caspase inhibition in this context does not restore any viral production. Owing to the lack of satisfactory tools, human HRT18jap1 cells were used as a study model but might not be appropriate to reveal N caspase cleavage relevance, notably for virus production. Further digging will thus be needed to understand the biological significance of N processing by caspases on TGEV infection.

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