Author: Jorge Blazquez-Prieto; Covadonga Huidobro; Ines Lopez-Alonso; Laura Amado-Rodriguez; Paula Martin-Vicente; Cecilia Lopez-Martinez; Irene Crespo; Cristina Pantoja; Pablo J Fernandez-Marcos; Manuel Serrano; Jacob I Sznajder; Guillermo M Albaiceta
Title: Cellular senescence limits acute lung injury induced by mechanical ventilation Document date: 2020_3_25
ID: ebwxryai_2
Snippet: Mechanotransduction is thought to regulate the molecular steps in VILI pathogenesis (6) . The nuclear envelope has been reported as an important cell mechanosensor (7) . Mechanical stretch appears to increase Lamin-A in the nuclear envelope, leading to nuclear stiffening. Inhibition of this response has been shown to decrease VILI in an experimental model (8) . Abnormalities in the nuclear envelope can also activate senescence (9) , a cell respon.....
Document: Mechanotransduction is thought to regulate the molecular steps in VILI pathogenesis (6) . The nuclear envelope has been reported as an important cell mechanosensor (7) . Mechanical stretch appears to increase Lamin-A in the nuclear envelope, leading to nuclear stiffening. Inhibition of this response has been shown to decrease VILI in an experimental model (8) . Abnormalities in the nuclear envelope can also activate senescence (9) , a cell response characterized by an stable arrest of the cell cycle and a switch towards a senescence-associated secretory phenotype (SASP) (10). This secretome includes a variety of molecules such as proinflammatory mediators and matrix metalloproteases, which in turn may induce senescence in a paracrine fashion (11) . It has been proposed that senescence . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.24.005983 doi: bioRxiv preprint 5 facilitates the clearance of damaged cells and is required for tissue repair (12) .
Search related documents:
Co phrase search for related documents- cell cycle and experimental model: 1, 2, 3
- cell cycle and mechanical stretch: 1, 2
- cell cycle and nuclear envelope: 1, 2
- cell cycle stable arrest and damaged cell: 1
- cell response and damaged cell: 1, 2
- cell response and experimental model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- cell response and mechanical stretch: 1, 2
- cell response and nuclear envelope: 1, 2, 3
- Lamin increase and mechanical stretch: 1
- Lamin increase and nuclear envelope: 1
- Lamin increase and nuclear envelope Lamin increase: 1
- mechanical stretch and nuclear envelope: 1, 2, 3
- mechanical stretch and nuclear envelope Lamin increase: 1
Co phrase search for related documents, hyperlinks ordered by date