Selected article for: "fat content and liver fat content"
Author: Baumeier, Christian; Schlüter, Luisa; Saussenthaler, Sophie; Laeger, Thomas; Rödiger, Maria; Alaze, Stella Amelie; Fritsche, Louise; Häring, Hans-Ulrich; Stefan, Norbert; Fritsche, Andreas; Schwenk, Robert Wolfgang; Schürmann, Annette
Title: Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease
  • Document date: 2017_8_4
    • ID: 64az0pco_18
    Snippet: We have recently shown that individuals with elevated levels of hepatic steatosis show an increased expression of DPP4 in the liver and that the liver substantially contributes to circulating DPP4 levels [23] . Here, we analyzed the plasma DPP4 activity of NAFLD patients with prediabetes in comparison to age-and sex-matched healthy controls. As expected, NAFLD subjects revealed an increased liver fat content ( Figure 1A ) and reduced insulin sens.....
    Document: We have recently shown that individuals with elevated levels of hepatic steatosis show an increased expression of DPP4 in the liver and that the liver substantially contributes to circulating DPP4 levels [23] . Here, we analyzed the plasma DPP4 activity of NAFLD patients with prediabetes in comparison to age-and sex-matched healthy controls. As expected, NAFLD subjects revealed an increased liver fat content ( Figure 1A ) and reduced insulin sensitivity ( Figure 1B ). DPP4 activity was augmented in plasma of NAFLD patients ( Figure 1C , 52.8 AE 1.2 vs. 49.9 AE 1.0, p < 0.05), indicating an increased release of the enzyme into the circulation. However, as BMI was also higher in the NAFLD group (33.9 AE 0.5 vs. 26.6 AE 0.6, p < 0.001), increased plasma DPP4 activity could also be originated from elevated adipose tissue mass.

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