Author: Baumeier, Christian; Schlüter, Luisa; Saussenthaler, Sophie; Laeger, Thomas; Rödiger, Maria; Alaze, Stella Amelie; Fritsche, Louise; Häring, Hans-Ulrich; Stefan, Norbert; Fritsche, Andreas; Schwenk, Robert Wolfgang; Schürmann, Annette
Title: Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease Document date: 2017_8_4
ID: 64az0pco_5
Snippet: Hepatocyte-specific Dpp4 transgenic mice (Dpp4-Liv-Tg) were generated by the company genOway (Lyon, France) via Hprt (hypoxanthine phosphoribosyl-transferase) targeted transgenesis. The knock-in targeting vector, containing murine Dpp4 cDNA under the control of an albumin promoter, was transfected into E14 ES cells (129P2/Ola), which were injected into C57BL/6J blastocysts. Obtained chimeras were backcrossed seven times with C57BL/6J mice. Threew.....
Document: Hepatocyte-specific Dpp4 transgenic mice (Dpp4-Liv-Tg) were generated by the company genOway (Lyon, France) via Hprt (hypoxanthine phosphoribosyl-transferase) targeted transgenesis. The knock-in targeting vector, containing murine Dpp4 cDNA under the control of an albumin promoter, was transfected into E14 ES cells (129P2/Ola), which were injected into C57BL/6J blastocysts. Obtained chimeras were backcrossed seven times with C57BL/6J mice. Threeweek-old male Dpp4-Liv-Tg mice (n ¼ 9) and wild-type (WT, n ¼ 7) littermates received a high-fat diet (HFD, 45 2.3. Blood glucose, body weight, body composition, and liver fat content Body weight was measured every other week. Blood glucose was measured using a CONTOUR Ò XT glucometer (Bayer). At 6, 18, and 26 weeks of age body composition and liver fat content were analyzed using nuclear magnetic resonance and computed tomography (CT) as described before [26] .
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