Selected article for: "apoptosis pathway and intrinsic pathway"
Author: Dong, Xiaoxv; Ni, Boran; Fu, Jing; Yin, Xingbin; You, Longtai; Leng, Xin; Liang, Xiao; Ni, Jian
Title: Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase-dependent pathway
  • Document date: 2018_8_2
    • ID: 02r8i5n1_1
    Snippet: Apoptosis is a highly regulated and genetically programmed cell death process. It is driven through the death receptor-mediated extrinsic pathway and mitochondrial-mediated intrinsic pathway (1) (2) (3) , which plays a pivotal role in the programmed cell death of mammalian cells (4) . Reactive oxygen species (ROS) plays an important role in apoptosis by regulating the intrinsic mitochondrial apoptosis pathway (5) . An increase in ROS production r.....
    Document: Apoptosis is a highly regulated and genetically programmed cell death process. It is driven through the death receptor-mediated extrinsic pathway and mitochondrial-mediated intrinsic pathway (1) (2) (3) , which plays a pivotal role in the programmed cell death of mammalian cells (4) . Reactive oxygen species (ROS) plays an important role in apoptosis by regulating the intrinsic mitochondrial apoptosis pathway (5) . An increase in ROS production regulates Bcl-2 family members, such as Bax and Bcl-2. Changes in the Bax/Bcl-2 ratio result in the release cytochrome c, which then activates caspase-3 and cleaves PARP, leading to cell death through the mitochondrial death pathway (6) (7) (8) .

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