Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

Lee, Hyun Jun; Seo, Young Eun; Han, Seung Beom; Jeong, Dae Chul; Kang, Jin Han

In total, 105 children were diagnosed with an ADV infection during the study period. The median age at enrollment was 29 months (range: 0-131 months), and 60 (57.1%) children were males. On admission, 104 (99.0%) children complained of fever, and the fever persisted for a median of 5 days (range: 0-13 days) [starting 3 days (range: 0-10 days) before admission and persisting until 2 days (range: 0-5 days) after admission]. Among the local symptoms presented on admission, respiratory symptoms (87 children, 82.9%) were the most frequent, followed by gastrointestinal (24 children, 22.9%) and ophthalmologic (18 children, 17.1%) symptoms. Among gastrointestinal symptoms, diarrhea (17 children, 70.8%) was most frequent, and vomiting (11 children, 45.8%) and abdominal pain (7 children, 29.2%) followed. Febrile seizures occurred in four (3.8%) children. Five children (4.8%) showed fever without localizing signs. URTI and LRTI were diagnosed in 56 (53.3%), and 32 (30.5%) children, respectively. Thirteen (12.4%) children had underlying medical conditions. Eleven (10.5%) children were born prematurely and eight (7.6%) of them also had a previous history of bronchopulmonary dysplasia (BPD); one child had an underlying congenital hypotonia and had experienced recurrent pneumonia since birth; and one child received corrective surgery for esophageal atresia and experienced recurrent respiratory tract infections since the surgery.