Author: Jorge Blazquez-Prieto; Covadonga Huidobro; Ines Lopez-Alonso; Laura Amado-Rodriguez; Paula Martin-Vicente; Cecilia Lopez-Martinez; Irene Crespo; Cristina Pantoja; Pablo J Fernandez-Marcos; Manuel Serrano; Jacob I Sznajder; Guillermo M Albaiceta
Title: Cellular senescence limits acute lung injury induced by mechanical ventilation Document date: 2020_3_25
ID: ebwxryai_43
Snippet: We then explored the molecular mechanisms participating in this senescent response to acute injury. Lamins in the nuclear envelope act as cell mechanosensors, regulating chromatin organization in response to mechanical stress, and their abnormalities may lead to accelerated aging (9) . We observed that Lamin-A increased after mechanical stretch, with no changes in Lamin-B1 ( Figure 3A )......
Document: We then explored the molecular mechanisms participating in this senescent response to acute injury. Lamins in the nuclear envelope act as cell mechanosensors, regulating chromatin organization in response to mechanical stress, and their abnormalities may lead to accelerated aging (9) . We observed that Lamin-A increased after mechanical stretch, with no changes in Lamin-B1 ( Figure 3A ).
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