Title: Coronavirus induction of class I major histocompatibility complex expression in murine astrocytes is virus strain specific Document date: 1994_9_1
ID: 4bf8eiix_5
Snippet: In this communication, we have examined the ability of a panel of MHV strains to induce class I expression in cultures enriched at least 95% for astrocytes. The data indicate that class I expression occurred in response to all the MHV strains tested except JHMV and virus strains derived from JHMV. Additional studies show that class I expression requires the presence of infectious virus. Finally, the testing of A59/JHMV recombinant viral strains s.....
Document: In this communication, we have examined the ability of a panel of MHV strains to induce class I expression in cultures enriched at least 95% for astrocytes. The data indicate that class I expression occurred in response to all the MHV strains tested except JHMV and virus strains derived from JHMV. Additional studies show that class I expression requires the presence of infectious virus. Finally, the testing of A59/JHMV recombinant viral strains suggests that the class I-inducing activity resides in the 3' end of the A59 genome, possibly in one of the genes encoding the structural proteins.
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