Author: Hayward, Gail; Thompson, Matthew; Heneghan, Carl; Perera, Rafael; Del Mar, Chris; Glasziou, Paul
Title: Corticosteroids for pain relief in sore throat: systematic review and meta-analysis Document date: 2009_8_6
ID: 67bhdlzy_3
Snippet: The pressure for clinicians to reduce antibiotic prescriptions for sore throat leaves a therapeutic vacuum. Corticosteroids inhibit transcription of proinflammatory mediators in human airway endothelial cells which cause pharyngeal inflammation and ultimately symptoms of pain.15 Corticosteroids are beneficial in other upper respiratory tract infections such as acute sinusitis, croup, and infectious mononucleosis.16
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18 We therefore hypothesised.....
Document: The pressure for clinicians to reduce antibiotic prescriptions for sore throat leaves a therapeutic vacuum. Corticosteroids inhibit transcription of proinflammatory mediators in human airway endothelial cells which cause pharyngeal inflammation and ultimately symptoms of pain.15 Corticosteroids are beneficial in other upper respiratory tract infections such as acute sinusitis, croup, and infectious mononucleosis.16
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18 We therefore hypothesised that corticosteroids would offer similar symptomatic relief from sore throat because of their anti-inflammatory effects, and undertook a systematic review to examine the effect of systemic corticosteroids on adults and children with sore throat.
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