Author: Wassenaar, Trudy M.; Jun, Se-Ran; Robeson, Michael; Ussery, David W.
Title: Comparative genomics of hepatitis A virus, hepatitis C virus, and hepatitis E virus provides insights into the evolutionary history of Hepatovirus species Document date: 2019_11_19
ID: 3hayxyuk_34
Snippet: Alternatively, a possible ancestor with a codon usage that was adapted to an alternative host must be sought in a more distant evolutionary history. If such an ancestor virus once existed, it more likely replicated in a host with a GC content much lower than that of mammals, as the overall codon usage of mammalian cells does not vary much between species. Instead, codon usage in mammals is primarily governed by within-genome variation in GC conte.....
Document: Alternatively, a possible ancestor with a codon usage that was adapted to an alternative host must be sought in a more distant evolutionary history. If such an ancestor virus once existed, it more likely replicated in a host with a GC content much lower than that of mammals, as the overall codon usage of mammalian cells does not vary much between species. Instead, codon usage in mammals is primarily governed by within-genome variation in GC content, and only weakly, if at all, correlates to gene expression and tRNA content (Galtier et al., 2018) .
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