Author: Abes, Rachida; Moulton, Hong M.; Clair, Philippe; Yang, Sung-Tae; Abes, Said; Melikov, Kamran; Prevot, Paul; Youngblood, Derek S.; Iversen, Patrick L.; Chernomordik, Leonid V.; Lebleu, Bernard
Title: Delivery of steric block morpholino oligomers by (R-X-R)(4) peptides: structure–activity studies Document date: 2008_9_16
ID: 5j496cx0_62
Snippet: We thus tentatively conclude at this stage that (R-X-R) 4 -PMO accumulate in cytoplasmic vesicles after binding to cell surface glycosaminoglycans and endocytosis. Differences in splicing correction might thus be primarily due to the efficiency with which these conjugates escape from endocytic vesicles and reach the cytoplasm......
Document: We thus tentatively conclude at this stage that (R-X-R) 4 -PMO accumulate in cytoplasmic vesicles after binding to cell surface glycosaminoglycans and endocytosis. Differences in splicing correction might thus be primarily due to the efficiency with which these conjugates escape from endocytic vesicles and reach the cytoplasm.
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