Selected article for: "avian iav and human human"
Author: Hayden C. Metsky; Katherine J. Siddle; Adrianne Gladden-Young; James Qu; David K. Yang; Patrick Brehio; Andrew Goldfarb; Anne Piantadosi; Shirlee Wohl; Amber Carter; Aaron E. Lin; Kayla G. Barnes; Damien C. Tully; Björn Corleis; Scott Hennigan; Giselle Barbosa-Lima; Yasmine R. Vieira; Lauren M. Paul; Amanda L. Tan; Kimberly F. Garcia; Leda A. Parham; Ikponmwonsa Odia; Philomena Eromon; Onikepe A. Folarin; Augustine Goba; Etienne Simon-Lorière; Lisa Hensley; Angel Balmaseda; Eva Harris; Douglas Kwon; Todd M. Allen; Jonathan A. Runstadler; Sandra Smole; Fernando A. Bozza; Thiago M. L. Souza; Sharon Isern; Scott F. Michael; Ivette Lorenzana; Lee Gehrke; Irene Bosch; Gregory Ebel; Donald Grant; Christian Happi; Daniel J. Park; Andreas Gnirke; Pardis C. Sabeti; Christian B. Matranga
Title: Capturing diverse microbial sequence with comprehensive and scalable probe design
  • Document date: 2018_3_12
    • ID: a9lkhayg_22
    Snippet: We then evaluated how well our V ALL and V WAFR probe sets capture sequence that is divergent from sequences used in their design. To do this, we tested whether the probe sets, whose designs included human IAV, successfully enrich the genome of the non-human, avian subtype H4N4 (IAV-SM5). H4N4 was not included in the designs, making it a useful test case for this relationship. Moreover, the IAV genome has 8 RNA segments that differ considerably i.....
    Document: We then evaluated how well our V ALL and V WAFR probe sets capture sequence that is divergent from sequences used in their design. To do this, we tested whether the probe sets, whose designs included human IAV, successfully enrich the genome of the non-human, avian subtype H4N4 (IAV-SM5). H4N4 was not included in the designs, making it a useful test case for this relationship. Moreover, the IAV genome has 8 RNA segments that differ considerably in their genetic diversity; segment 4 (hemagglutinin; H) and segment 6 (neuraminidase; N), which are used to define the subtypes, exhibit the most diversity.

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