Selected article for: "gene ontology and high expression"
Author: Monika Litvinukova; Carlos Talavera-Lopez; Henrike Maatz; Daniel Reichart; Catherine L. Worth; Eric L. Lindberg; Masatoshi Kanda; Krzysztof Polanski; Eirini S. Fasouli; Sara Samari; Kenny Roberts; Elizabeth Tuck; Matthias Heinig; Daniel DeLaughter; Barbara McDonough; Hiroko Wakimoto; Joshua M. Gorham; Emily Nadelmann; Krishnaa T. Mahbubani; Kourosh Saeb-Parsy; Giannino Patone; Joseph J Boyle; Hongbo Zhang; Hao Zhang; Anissa Viveiros; Gavin Oudit; Omer Bayraktar; J. G. Seidman; Christine Seidman; Michela Noseda; Norbert Hubner; Sarah A. Teichmann
Title: Cells and gene expression programs in the adult human heart
  • Document date: 2020_4_5
    • ID: 1ilforzm_13
    Snippet: We also identified two subpopulations (vCM3 and vCM4) across all ventricular regions. The transcriptional profile of vCM3 was remarkably similar to a prominent RA subpopulation (aCM3, discussed below), and suggestive that these are derived from the second heart field 18 . These cells had higher levels of transcripts associated with retinoic-acid responsive smooth muscle cell genes, including MYH9 , CNN1 19, 20 , and NEXN . vCM3 also expressed str.....
    Document: We also identified two subpopulations (vCM3 and vCM4) across all ventricular regions. The transcriptional profile of vCM3 was remarkably similar to a prominent RA subpopulation (aCM3, discussed below), and suggestive that these are derived from the second heart field 18 . These cells had higher levels of transcripts associated with retinoic-acid responsive smooth muscle cell genes, including MYH9 , CNN1 19, 20 , and NEXN . vCM3 also expressed stress-response genes including ANKRD1 21 , FHL1 22 , DUSP27 23 , XIRP1 and XIRP2. The XIRP proteins interact with cardiac ion channel proteins Nav1.5 and Kv1.5 within intercalated 8 . CC-BY-NC 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.03.024075 doi: bioRxiv preprint discs, and have been implicated in lethal cardiac arrhythmias prevalent in cardiomyopathies 26, 24 . vCM4 contributed 6-10% to vCM populations, and expressed nuclear-encoded mitochondrial genes ( NDUFB11 , NDUFA4 , COX7C , and COX5B ; Figure 2E ) suggestive of a high energetic state. Indeed, Gene Ontology analyses of vCM4 transcripts identified significant terms of "ATP metabolic process" and "oxidative phosphorylation" ( Supplementary Figure B1C ). These CM also had high levels of CRYAB encoding a heat shock protein with cytoprotective roles and antioxidant responses by CM 25 . With c oncomitant high expression of genes encoding sarcomere components ( Figure 2E ) and PLN ( Supplementary Table B3 ) , we deduced that these vCM are outfitted to perform higher workload than other vCM.

    Search related documents:
    Co phrase search for related documents
    • antioxidant response and heat shock: 1, 2
    • antioxidant response and heat shock protein: 1, 2
    • antioxidant response and high expression: 1
    • cardiac ion channel and ion channel: 1, 2, 3, 4, 5, 6
    • cell gene and heat shock: 1, 2, 3, 4, 5, 6
    • cell gene and heat shock protein: 1
    • cell gene and high expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cell gene and high level: 1, 2, 3, 4, 5, 6, 7, 8
    • cell gene and ion channel: 1, 2
    • cytoprotective role and high expression: 1
    • energetic state and high energetic state: 1
    • heat shock and high expression: 1, 2, 3, 4, 5
    • heat shock and high level: 1, 2
    • heat shock protein and high expression: 1
    • high expression and ion channel: 1, 2, 3, 4
    • high level and ion channel: 1, 2, 3