Author: Baek, Hyekyung; Kim, Kwang Ho; Park, Min Young; Kim, Kyeongryun; Ko, Bokyeong; Seo, Hyung Seok; Kim, Byoung Soo; Hahn, Tae-Wook; Yi, Sun Shin
Title: Establishment of minimal positive-control conditions to ensure brain safety during rapid development of emergency vaccines Document date: 2017_8_22
ID: 52sbckm3_37
Snippet: Further studies should be undertaken to identify the exact time PI at which TJ mRNA and protein levels are altered. This can be accomplished by narrowing the time intervals used in this study. Moreover, investigations into possible differences between male and female mice, and into establishment of double-check modules by applying other kinds of TJs including claudins or JAMs are needed. We are planning additional research to ensure the safety of.....
Document: Further studies should be undertaken to identify the exact time PI at which TJ mRNA and protein levels are altered. This can be accomplished by narrowing the time intervals used in this study. Moreover, investigations into possible differences between male and female mice, and into establishment of double-check modules by applying other kinds of TJs including claudins or JAMs are needed. We are planning additional research to ensure the safety of various vaccines, including those already in the market, by using this novel positive-control protocol. We expect that the protocol will be very useful in determining brain safety of urgently developed new vaccines.
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