Author: Monika Litvinukova; Carlos Talavera-Lopez; Henrike Maatz; Daniel Reichart; Catherine L. Worth; Eric L. Lindberg; Masatoshi Kanda; Krzysztof Polanski; Eirini S. Fasouli; Sara Samari; Kenny Roberts; Elizabeth Tuck; Matthias Heinig; Daniel DeLaughter; Barbara McDonough; Hiroko Wakimoto; Joshua M. Gorham; Emily Nadelmann; Krishnaa T. Mahbubani; Kourosh Saeb-Parsy; Giannino Patone; Joseph J Boyle; Hongbo Zhang; Hao Zhang; Anissa Viveiros; Gavin Oudit; Omer Bayraktar; J. G. Seidman; Christine Seidman; Michela Noseda; Norbert Hubner; Sarah A. Teichmann
Title: Cells and gene expression programs in the adult human heart Document date: 2020_4_5
ID: 1ilforzm_27
Snippet: The heart is innervated by both sympathetic and parasympathetic components of the autonomic nervous system, which reside in ganglionated plexuses on the epicardial surface and contribute to regulation of heart rhythm 67 . Neural cells (NC) innervate the sinoatrial and atrioventricular nodes, from which an activating wave-front propagates throughout myocardial tissue via nerve bundles and Purkinje fibers. We identified 3485 NC from cardiac tissues.....
Document: The heart is innervated by both sympathetic and parasympathetic components of the autonomic nervous system, which reside in ganglionated plexuses on the epicardial surface and contribute to regulation of heart rhythm 67 . Neural cells (NC) innervate the sinoatrial and atrioventricular nodes, from which an activating wave-front propagates throughout myocardial tissue via nerve bundles and Purkinje fibers. We identified 3485 NC from cardiac tissues, predominantly (60%) from left chambers, presumably due to multiple left ventricular sites. All NC expressed transcripts ( NRXN1, NRXN3, KCNMB4 ) typically found in the central nervous and cardiac conduction system including sodium and potassium channels 68 ( Supplementary Table F1 ) .
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