Selected article for: "ancestral regression and de novo regression line"
Author: Sabath, Niv; Wagner, Andreas; Karlin, David
Title: Evolution of Viral Proteins Originated De Novo by Overprinting
  • Document date: 2012_7_19
    • ID: 629fwmgk_16
    Snippet: Codon Similarity Index Figure 4 presents the CSI values of ancestral and de novo genes. The slopes of the two regression lines show a significant difference (P < 0.032). The slope of the ancestral regression line is not significantly different from zero (P > 0.96), whereas the de novo regression line has a positive slope (P < 0.003). Relative to their ancestral overlapping genes, most de novo genes show lower CSI values, although the ranges of CS.....
    Document: Codon Similarity Index Figure 4 presents the CSI values of ancestral and de novo genes. The slopes of the two regression lines show a significant difference (P < 0.032). The slope of the ancestral regression line is not significantly different from zero (P > 0.96), whereas the de novo regression line has a positive slope (P < 0.003). Relative to their ancestral overlapping genes, most de novo genes show lower CSI values, although the ranges of CSI values in de novo and ancestral genes overlap markedly in most groups. An exception is omegatetraviruses (taxon 4), in which the CSI values of the de novo p17 genes are all higher than the CSI values of the ancestral capsid genes. The CSI values for homologous genes can take a wide range of values. For instance, the CSI of the betacoronavirus I gene varies from 0.27 to 0.67. Overall, the data suggest that the codon usage of de novo genes becomes slowly assimilated into that of the host genome.

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